Reproductive and Developmental
Sciences Training Program

 


Reproductive and Developmental

Sciences Training Program

artiro sen thumb

EDUCATION/DEGREE INFORMATION

PhD, Biology (CMB Program) - West Virginia University, Morgantown

MS, Biochemistry - University of Calcutta, India,

BS, Microbiology - Bangalore University, India

Postdoctoral Research, Reproductive Endocrinology – Michigan State University, East Lansing

Postdoctoral Research, Molecular Endocrinology - University of Texas Southwestern Medical Center, Dallas

Dr. Sen received his undergraduate degree in Microbiology with minor in Chemistry and Zoology from Bangalore University followed by Masters degree in Biochemistry from University of Calcutta, India. Thereafter he joined the PhD program in Cell and Molecular Biology at West Virginia University. Following his PhD, Dr. Sen moved to Michigan State University for a post-doctoral fellowship in Reproductive Endocrinology in the Department of Animal Sciences. He did a second post-doctoral fellowship in Molecular Endocrinology with Dr. Stephen R Hammes in the Division of Endocrinology and Metabolism at University of Texas Southwestern Medical Center, Dallas. Dr. Sen then joined the University of Rochester Medical Center at Rochester, NY first as a Research Assistant Professor and later established his own laboratory in the Department of Medicine, Division of Endocrinology and Metabolism at University of Rochester School of Medicine and Dentistry. He also held an Adjunct Faculty position at The College of Brockport, State University of New York and was visiting research scientist at the Center for Human Reproduction in New York City. In August of 2017, Dr. Sen joined the Reproductive and Developmental Sciences Program at Michigan State University. He currently holds an Assistant Professor position in the Department of Animal Sciences at MSU. His research has been funded by the National Institute of Health (NIH), Michigan State University, Ferring Pharmaceuticals and the Foundation for Reproductive Medicine. He has published more than 32 peer-reviewed manuscripts and invited-reviews in leading scientific journals. Dr. Sen has been awarded the Endocrine Society’s Pfizer Early Career Investigator Award.

RESEARCH INTEREST

The main focus of the lab is to understand the role of steroids and hormones in health and disease. Specifically, the lab is interested in understanding the cross-talk between steroid-induced extranuclear kinase signaling and intranuclear transcription and its downstream physiological effects. To elucidate this “outside-inside” communication of steroid signaling, we initially concentrated towards understanding androgen actions in ovarian physiology and female fertility. Through development of different ovarian cell-specific knockout mouse models our laboratory established for the first time that androgens play a critical role female fertility. The lab has further elucidated that the physiological effects of androgen are mediated through a synergistic action between the androgen receptor-mediated nuclear and extra-nuclear signaling and this phenomenon is highly conserved across tissues (ovary and prostate cancer) and species (mouse to humans). Most recently, we have turned our attention towards understanding steroid-induced epigenetic modulation. We are trying to understand how prenatal exposure to steroids and hormones in the form of maternal/fetal pathologies, nutritional deficits/excess, lifestyle choices/stress, as well as medical interventions, re-programs the epigenome that in turn alters the developmental course of the fetus or offspring leading to long-term harmful outcomes that often culminate in adult pathologies. We have created animal models for steroid hormone prenatal exposure and are studying the underlying mechanism(s) and its effect on metabolism and fertility. The lab uses a wide range of mouse models, primary cell culture and cell lines as well as cell and molecular techniques, genomic and physiological tools.

RECENT PUBLICATIONS

  1. Xiaoting Ma, Emily Hayes, Anindita Biswas, Christina Seger, Hen Prizant, Stephen R Hammes, Aritro Sen. Androgen Induced Epigenetic Modulation in Mouse Ovaries Through Rapid and Long Term Inhibition of Ezh2. Endocrinology 2017.
  2. Emily Hayes, Vitaly Kushnir, Xiaoting Ma, Anindita Biswas, Hen Prizant, Norbert Gleicher, Aritro Sen. Intracellular mechanism of Anti-Müllerian Hormone (AMH) in regulation of follicular development. Molecular and Cellular Endocrinology, 2016 Sep 15;433:56-65.
  3. Xiaoting Ma, Emily Hayes, Hen Prizant, Rajesh K Srivastava, Stephen R Hammes, Aritro Sen. Leptin-induced CART (Cocaine-and Amphetamine-Regulated Transcript) is a novel intra-ovarian mediator of obesity-related infertility. 2016 Mar;157(3):1248-57.
  4. Sellix MT and Aritro Sen. Finding the Right Balance: Androgens at the Tipping Point of Fertility and Metabolism in Women. Endocrinology 2017 Mar1;158(3):467-469.
  5. Aritro Sen, Hen Prizant, Allison Light, Anindita Biswas, Emily Hayes, Ho-Joon Lee, David Barad, Norbert Gleicher, Stephen R Hammes. Androgens Regulate Ovarian Follicular Development by Increasing Follicle Stimulating Hormone Receptor and microRNA-125b Expression. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3008-13.