Department of Obstetrics Gynecology, and Reproductive Biology
Institute for Quantitative Health Science and Engineering
My interests lie in understanding cellular and developmental mechanisms that underlie tissue morphogenesis and organ formation. During the course of my graduate work, I worked on teasing apart the role of canonical Wnt signaling downstream of T-box transcription factor Tbx4, in the mammalian placenta, and role of Fgf signaling downstream of Tbx4 and Tbx5 in the developing lung and trachea. As a post-doctoral fellow, I demonstrated the importance of spatial analysis of cellular events like meiosis in addition to population level analysis. Further, to understand biology at an organ level, I developed a technique for imaging and analyzing organization of the uterine structure in 3D. Using this methodology we have observed dynamic changes in the structure of the murine uterine lumen and glandular architecture as the window of receptivity approaches. In my laboratory we will combine the strengths of classic developmental biology methods, mouse genetics, organ culture, 3D imaging, computational image analysis and gene expression analysis, to establish how hormones influence the uterine luminal and glandular epithelium to modulate receptivity and implantation. Our long-term goal is to determine how aberrations in uterine structure at the time of implantation can affect the process of decidualization and placentation contributing to miscarriage, placental abnormalities, intra-uterine growth restriction and preterm birth.
- Uterine Biology
- Maternal Fetal interactions
- Developmental Genetics
- Early embryo development