Reproductive and Developmental
Sciences Training Program

 


Reproductive and Developmental

Sciences Training Program

drewlo thumb

 

EDUCATION

  • M.Sc. in 2000 from the University of Münster in Germany
  • Ph.D. from German Sport University, Cologne, Germany in 2006
  • Postdoctoral training at the Lulenfeld Tanenbaum Research Institute, University of Toronto, Canada

 

BIOGRAPHY

Sascha Drewlo, Ph.D. received his M.Sc. in 2000 from the University of Münster in Germany and his Ph.D. from Germon Sport University, Cologne, Germany in 2006. Following his postdoctoral training at the Lulenfeld Tanenbaum Research Institute, University of Toronto, Canada, he was appointed Assistant Professor in the Department of Obstetrics, Gynecology and Reproductive Biology at Wayne State University.  He has since been awarded the Basil O'Connor Stater Scholar Research Award from 2014 to 2016 in addition to the Gabor Than Award in 2016, which acknowledges outstanding contributions to the field of placentology to an early career investigator. He was then appointed Associate Professor in the Department of Obstetrics, Gynecology and Reproductive Biology at Wayne State University from 2016 to 2017. Dr. Drewlo is currently an Associate Professor in the Department of Obstetrics, Gynecology and Reproductive Biology in the College of Human Medicine at Michigan State University.

 

RESEARCH

The goal of my research is to close the gap between the diagnosis of placental dysfunction and its treatment. I have interests in the early detection of fetal and placental disorders along with deciphering the underlying molecular mechanisms of abnormal placentation to ultimately develop novel intervention strategies for preeclampsia as well as preterm birth and intrauterine growth restriction.

I furthermore investigate the potential of cervical trophoblast for novel non-invasive fetal diagnosis (Science Translational Medicine, 2016). Our research, and research in collaboration with Dr. Armant at Advanced Reproductive Testing, LLC, develops novel approaches for fetal genetic analysis as well as overall pregnancy status during the first trimester of pregnancy from a simple pap smear. This has the potential to change the way to assess pregnancies as it can be safely performed at as early as 5 weeks.

 

AREAS OF EXPERTISE

  • Human trophoblast cell differentiation
  • Biotechnology
  • Placental Biology
  • Automated Assay Development
  • Early Human Development
  • Fetal Complications

 

REFERENCES

 

(Baczyk, Drewlo et al. 2009, McCarthy, Drewlo et al. 2011, Fritz, Kohan-Ghadr et al. 2015, McLaughlin, Drewlo et al. 2015, Jain, Kadam et al. 2016)

Baczyk, D., S. Drewlo, L. Proctor, C. Dunk and S. Lye (2009). "Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast." Cell Death & Differentiation 16(5): 719-727.

Fritz, R., H.-R. Kohan-Ghadr, J. M. Bolnick, A. D. Bolnick, B. A. Kilburn, M. P. Diamond, S. Drewlo and D. R. Armant (2015). "Noninvasive detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC)." Fertility and sterility 104(2): 339-346. e334.

Jain, C. V., L. Kadam, M. van Dijk, H.-R. Kohan-Ghadr, B. A. Kilburn, C. Hartman, V. Mazzorana, A. Visser, M. Hertz and A. D. Bolnick (2016). "Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal." Science translational medicine 8(363): 363re364-363re364.

McCarthy, F. P., S. Drewlo, E. J. Johns, S. K. Walsh and L. C. Kenny (2011). "Peroxisome proliferator-activated receptor-γ as a potential therapeutic target in the treatment of preeclampsia." Hypertension: HYPERTENSIONAHA. 111.172627.

McLaughlin, K., S. Drewlo and J. D. Parker (2015). "Current theories on the prevention of severe preeclampsia with low-molecular weight heparin." Hypertension 66(6): 1098-1103.

 

 

PUBLICATIONS

 

http://www.ncbi.nlm.nih.gov/sites/myncbi/sascha.drewlo.1/bibliography/47436537/public/?sort=date&direction=ascending