Ryan’s ongoing doctoral research is focused on the endometrial compartment-specific function of ARID1A, a SWI/SNF chromatin remodeling complex protein, as it relates to endometriosis-related infertility. ARID1A expression is reduced in endometrium from women affected by endometriosis, a condition in which endometrial tissue grows outside the uterine cavity causing pelvic pain and infertility, but the pathophysiological significance is unclear. Utilizing an innovative endometriosis mouse model, conditional Arid1a knockout mice, and clinical biopsy samples will provide insight into the relationship between ARID1A loss and endometrial non-receptivity in the context of endometriosis.
- Marquardt, R.M., Kim, T.H., Shin, J.H., and Jeong, J.W. (2019). Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? J. Mol. Sci. 20(15), 3822. PMID: 31387263.
- Marquardt, R.M., Lee, K.L., Lee, B., Kim, T.H., DeMayo, F.J., and Jeong, J.W. (2020). Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus. Biology of Reproduction PMID: 32558878.
- Marquardt, R.M., Kim T.H., Yoo, J.Y., Teasley, H.E., Fazleabas, A.T., Young, S.L., Lessey, B.A, Arora, R., and Jeong, J.W. Endometrial epithelial ARID1A loss causes gland dysfunction in endometriosis and non-receptive endometrium. In Review.
- Marquardt, R.M., Jeong, J.W., and Fazleabas, A.T. Animal models of adenomyosis. In Review.
Ryan volunteered with the Rare Disease Day Symposium at Calvin University, which exists to bring together patients, families, and researchers from the rare disease community to gain a deeper understanding of each other and to learn how to support the community.