Genna’s focus is on endometriosis, an inflammatory and estrogen-dependent chronic gynecological disorder that affects approximately ten percent of reproductive aged women. Endometriosis is characterized by endometrium found at ectopic sites and induces a decidualization defect in eutopic endometrial stromal cells leading to infertility. She is investigating the interactions between two pathways that are critical for decidualization success, the HIPPO and NOTCH signaling pathways, with the aim of identifying the molecular mechanisms driving decidualization and investigating how these mechanisms may become aberrant in women with endometriosis thereby contributing to decidualization defects.
Wilson MR, Reske JJ, Holladay J, Wilber GE, Rhodes M, Koeman J, Adams M, Johnson B, Su R, Joshi NR, Patterson AL, Shen H, Leach RE, Teixeira JM, Fazleabas AT, Chandler RL. ARID1A and PI3-Kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Comm. 2019 Aug 7; 10(1):3554. doi:10.1038/s41467-019-11403-6. PubMed PMID: 31391455
Genna volunteered with Michigan State University’s Graduate Women in Science for Girls Math and Science Day. Girls Math and Science Day is an opportunity for middle school girls to participate in science and math-based activities lead by science students and researchers at MSU.